Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate

Base Information

Chemical Name:Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate
CAS No.:137522-48-6
Molecular Formula:C₁₇H₁₇N₃O₂
Molecular Weight:295.341
Hs Code.:
DSSTox Substance ID:DTXSID901159243
Nikkaji Number:J418.752K
ChEMBL ID:CHEMBL1566681

Synonyms:SMR000044531;MLS000040288;ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate;137522-48-6;cid_663782;CHEMBL1566681;BDBM62604;DTXSID901159243;HMS2433E19;STL343287;AKOS022124332;6-benzylamino-2-methyl-5-cyano-3-ethoxycarbonyl-pyridine;6-(benzylamino)-5-cyano-2-methyl-nicotinic acid ethyl ester;2-Methyl-5-cyano-6-benzylaminopyridine-3-carboxylic acid ethyl ester;Ethyl 5-cyano-2-methyl-6-[(phenylmethyl)amino]-3-pyridinecarboxylate;ethyl 5-cyano-2-methyl-6-[(phenylmethyl)amino]pyridine-3-carboxylate;5-cyano-2-methyl-6-[(phenylmethyl)amino]-3-pyridinecarboxylic acid ethyl ester

Suppliers and Price of Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:295.132076794
Heavy Atom Count:22
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(C(=C1)C#N)NCC2=CC=CC=C2)C

Technology Process of Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate

There total 2 articles about Ethyl 6-(benzylamino)-5-cyano-2-methylpyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 64119-42-2
ethyl 6-chloro-5-cyano-2-methylnicotinate

: 100-46-9
benzylamine

: 137522-48-6
6-(benzylamino)-5-cyano-2-methylnicotinic acid ethyl ester

Guidance literature:: In toluene; for 1h; Heating;
DOI:10.1007/BF02464283

Reference yield:

: 52600-52-9
5-Cyano-2-methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

: 137522-48-6
6-(benzylamino)-5-cyano-2-methylnicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / POCl₃ / 1 h / Heating

2: 81 percent / toluene / 1 h / Heating

With trichlorophosphate; In toluene; 1: Aromatisation / 2: Substitution;
DOI:10.1007/BF02464283