(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane
CAS No.:85362-87-4
Molecular Formula:C₂₁H₂₄Cl₂O₄
Molecular Weight:411.325
Hs Code.:

Synonyms:(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of (4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

There total 5 articles about (4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85362-86-3
(2R,3R)-(+)-1,4-bis(4-chlorobenzyloxy)butane-2,3-diol

: 85362-87-4
(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / H₂O; benzene / 13 h / Heating

2: 70 percent / acetone / boron trifluoride-etherate / 13 h / Heating

With toluene-4-sulfonic acid; acetone; boron trifluoride diethyl etherate; In water; benzene;
DOI:10.1016/S0040-4020(01)91522-4

Reference yield:

: 73346-73-3
(4S,5S)-diethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

: 85362-87-4
(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium hydride

2: 1) sodium hydride / 1) THF, r.t., 30 min; 2) THF, 50 deg C, 3 h

With lithium aluminium tetrahydride; sodium hydride;
DOI:10.1016/S0040-4020(01)91522-4

Reference yield:

: 3969-59-3,4239-88-7,81704-51-0
(+)-1,2,3,4,5,6-tris-O-isopropylidene-D-mannitol

: 85362-87-4
(4R,5R)-(+)-4,5-bis(4-chlorobenzyloxymethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / aq. AcOH

2: 1) NaIO₄; 2) sodium borohydride

3: 1) sodium hydride / 1) THF, r.t., 30 min; 2) THF, 50 deg C, 3 h

With sodium tetrahydroborate; sodium periodate; sodium hydride; acetic acid;
DOI:10.1016/S0040-4020(01)91522-4