1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

Base Information

Chemical Name:1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid
CAS No.:937054-52-9
Molecular Formula:C₂₅H₂₂ClFN₄O₅
Molecular Weight:512.925
Hs Code.:

Synonyms:1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

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Chemical Property of 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

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Technology Process of 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

There total 11 articles about 1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937054-50-7
1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-carboxylic acid ethyl ester

: 937054-52-9
1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: 1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-carboxylic acid ethyl ester; With methanol; water; potassium carbonate; In tetrahydrofuran; at 55 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 937057-60-8
(5-chloro-3-fluoro-2-pyrrol-1-ylphenyl)-(2,3-dimethoxyphenyl)methanol

: 937054-52-9
1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: manganese(IV) oxide / dichloromethane / 14 h / 20 °C / Heating / reflux

2.1: trichlorophosphate / 0.25 h / 0 - 20 °C

2.2: 2.08 h / 0 - 50 °C

2.3: 0.5 h / 50 °C

3.1: toluene / 1 h / Heating / reflux

4.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

4.2: 0 °C

5.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

6.1: Resolution of racemate

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

7.2: 0 °C

8.1: triethylamine / dichloromethane / 1 h / 0 °C

9.1: sodium azide / water; N,N-dimethyl-formamide / 13 h / 80 °C

10.1: toluene / 8 h / Heating / reflux

11.1: methanol; water; potassium carbonate / tetrahydrofuran / 1 h / 55 °C

11.2: 0 °C

With methanol; manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; water; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 937057-62-0
1-[4-Chloro-2-(2,3-dimethoxybenzoyl)-6-fluorophenyl]-1H-pyrrolo-2-carbaldehyde

: 937054-52-9
1-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-10-fluoro-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene / 1 h / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

2.2: 0 °C

3.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C

4.1: Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

5.2: 0 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: sodium azide / water; N,N-dimethyl-formamide / 13 h / 80 °C

8.1: toluene / 8 h / Heating / reflux

9.1: methanol; water; potassium carbonate / tetrahydrofuran / 1 h / 55 °C

9.2: 0 °C

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; water; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;