spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

Base Information

Chemical Name:spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester
CAS No.:1356928-22-7
Molecular Formula:C₁₉H₂₁N₃O₂
Molecular Weight:323.395
Hs Code.:

Synonyms:spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

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Chemical Property of spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

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Technology Process of spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

There total 3 articles about spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1301214-81-2
8-(dimethylaminomethylene)-9-oxo-3-azaspiro[5.5]undec-10-ene-3-carboxylic acid benzyl ester

: 1356928-22-7
spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

Guidance literature:: With hydrazine hydrate; acetic acid; In ethanol; at 90 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo202377g

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1356928-22-7
spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / benzene / 24 h / 70 - 110 °C / Inert atmosphere

2: toluene / 5 h / 110 °C / Inert atmosphere

3: hydrazine hydrate; acetic acid / ethanol / 2 h / 90 °C / Inert atmosphere

With toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In ethanol; toluene; benzene; 1: Robinson annulation;
DOI:10.1021/jo202377g

Reference yield:

: 189333-18-4
3-oxo-9-azaspiro[5.5]undec-4-ene-9-carboxylic acid benzyl ester

: 1356928-22-7
spiro[1,4-dihydrobenzooxazole-5,4'-piperidine]-1'-formic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 5 h / 110 °C / Inert atmosphere

2: hydrazine hydrate; acetic acid / ethanol / 2 h / 90 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; In ethanol; toluene;
DOI:10.1021/jo202377g