2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

Base Information

Chemical Name:2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate
CAS No.:1609110-29-3
Molecular Formula:C₂₃H₃₄N₄O₂
Molecular Weight:398.549
Hs Code.:

Synonyms:2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

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Chemical Property of 2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

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Technology Process of 2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

There total 5 articles about 2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1609110-28-2
1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-carbohydrazide

: 78-39-7
Triethyl orthoacetate

: 1609110-29-3
2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

Guidance literature:: at 120 - 140 ℃; for 5h;
DOI:10.1016/j.bmcl.2014.03.098

Reference yield:

: 82625-46-5
4-(3-(piperidin-1-yl)propoxy)benzaldehyde

: 1609110-29-3
2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / Inert atmosphere

2: hydrazine hydrate / 96 h / Reflux

3: 5 h / 120 - 140 °C

With sodium tris(acetoxy)borohydride; hydrazine hydrate; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2014.03.098

Reference yield:

: 93543-57-8
3-piperidin-1-yl-propylamine hydrochloride

: 1609110-29-3
2-methyl-5-(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4-yl)-1,3,4-oxadiazoloxalate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; potassium carbonate / acetone / 48 h / Reflux

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5 h / Inert atmosphere

3: hydrazine hydrate / 96 h / Reflux

4: 5 h / 120 - 140 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; potassium iodide; In 1,2-dichloro-ethane; acetone;
DOI:10.1016/j.bmcl.2014.03.098