TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
• CAS No.: 132414-81-4
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.292
• Hs Code.: 2933990090
• Mol file: 132414-81-4.mol

Synonyms:Hexahydropyrrolo[3,4-b]pyrrole-5-carboxylicacid tert-butyl ester;tert-Butyl 2,7-diazabicyclo[3.3.0]octane-7-carboxylate;

Chemical Property of TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.13E-06mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 295.397 °C at 760 mmHg
• PKA: 10.72±0.20(Predicted)
• Flash Point: 132.451 °C
• PSA: 41.57000
• Density: 1.076g/cm³
• LogP: 1.48190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Tert-ButylHexahydropyrrolo[3,4-B]Pyrrole-5(1H)-Carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50/53-50
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

There total 7 articles about TERT-BUTYL HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate (132414-80-3) → tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (132414-81-4,180975-51-3)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol; for 2h; Inert atmosphere; Reflux;

Reference yield:

tert-butyldicarbonate (34619-03-9) → tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (132414-81-4,180975-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 20 °C

2: ammonium formate; palladium on activated charcoal / methanol / 2 h / Inert atmosphere; Reflux

With palladium on activated charcoal; ammonium formate; In methanol; dichloromethane;

Reference yield:

ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate (128740-02-3) → tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (132414-81-4,180975-51-3)

Guidance literature:

Multi-step reaction with 5 steps

1: formic acid / 0.5 h / Reflux

2: toluene / 4 h / Reflux

3: hydrogenchloride / water / 24 h / Reflux

4: dichloromethane / 4 h / 20 °C

5: ammonium formate; palladium on activated charcoal / methanol / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; formic acid; palladium on activated charcoal; ammonium formate; In methanol; dichloromethane; water; toluene;

upstream raw materials:

tert-butyldicarbonate

ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate

N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester

ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate

Refernces

• 1、 -. "Modulators of chemokine receptor activity". . . Retrieved 2008/06/13.
• 2、 -. "7-(2,7-diazabicyclo[3.3.0]octyl)-3-quinoline- and -naphthyridone-carboxylic acid derivatives". . . Retrieved 2008/06/13.