tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate
CAS No.:1369959-08-9
Molecular Formula:C₁₉H₂₁Cl₂N₃O₂
Molecular Weight:394.301
Hs Code.:

Synonyms:tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

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Chemical Property of tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

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Technology Process of tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

There total 1 articles about tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1694-31-1
tert-butyl acetoacetate

: 4-methyl-1H-pyrazol-5-amine

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1369959-08-9
tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Guidance literature:: With piperidine; In n-heptane; isopropyl alcohol; at 95 ℃; for 48h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield: 86.0%

: 1369959-08-9
tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: 1369959-18-1
7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-08-9
tert-butyl 7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: ((S)-7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)((S)-2-(4-fluorophenyl)pyrrolidin-1-yl)methanone

: 1369958-90-6
((R)-7-(3,4-dichlorophenyl)-3,5-dimethyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)((S)-2-(4-fluorophenyl)pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/jm201386u