3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

Base Information

Chemical Name:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid
CAS No.:1025763-75-0
Molecular Formula:C₂₃H₁₉FN₂O₂
Molecular Weight:374.414
Hs Code.:

Synonyms:3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

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Chemical Property of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

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Technology Process of 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

There total 4 articles about 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025765-44-9
methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoate

: 1025763-75-0
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

Guidance literature:: methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoate; With methanol; sodium hydroxide; water; In dimethyl sulfoxide; at 100 ℃;

With hydrogenchloride; In methanol; water; dimethyl sulfoxide; pH=5;

Reference yield:

: 3-(1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

: 352-34-1
4-fluoro-1-iodobenzene

: 1025763-75-0
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

Guidance literature:: With potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.06.089

Reference yield:

: 1025762-64-4
(1H-indazol-5-yl)(phenyl)methanol

: 1025763-75-0
3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-methyl-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride / dichloromethane / 12 h / 0 °C

2: sodium hydroxide / methanol; dimethyl sulfoxide / 12 h / 100 °C

3: copper(l) iodide; potassium phosphate / 1,4-dioxane / 24 h / 110 °C

With potassium phosphate; copper(l) iodide; titanium tetrachloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Mukaiyama Aldol Addition / 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.06.089