ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

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Chemical Name:ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate
CAS No.:1228375-22-1
Molecular Formula:C₂₁H₁₃Cl₂F₃N₄O₄
Molecular Weight:513.26
Hs Code.:

Synonyms:ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

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Chemical Property of ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

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Technology Process of ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

There total 1 articles about ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1228375-64-1
C₁₇H₆Cl₃F₃N₄O₂

: 6148-64-7
ethyl potassium malonate

: 1228375-22-1
ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

Guidance literature:: ethyl potassium malonate; With triethylamine; magnesium chloride; In ethyl acetate; at 0 - 5 ℃; for 18h;

C₁₇H₆Cl₃F₃N₄O₂; In ethyl acetate; at 20 ℃; Cooling with ice;

Reference yield: 94.2%

: 1228375-22-1
ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate

: 1228372-39-1
3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-hydroxypropanoic acid

Guidance literature:: ethyl 3-(3-chloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)-3-oxopropanoate; With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃;

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With acetic acid; In water; pH=4;