{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

Base Information

Chemical Name:{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid
CAS No.:1253210-85-3
Molecular Formula:C₁₉H₂₂FNO₄
Molecular Weight:347.386
Hs Code.:

Synonyms:{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

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Chemical Property of {2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

Chemical Property:

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Technology Process of {2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

There total 13 articles about {2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₄FNO₄

: 1253210-85-3
{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

Guidance literature:: C₂₀H₂₄FNO₄; With methanol; sodium hydroxide; at 50 ℃; for 1h;

With hydrogenchloride; In methanol; water; at 20 ℃;

Reference yield:

: 939430-71-4
6-chloro-5-methoxymethoxy-pyridine-2-carbaldehyde

: 1253210-85-3
{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2.83 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 11 h / 90 °C / Inert atmosphere

3.1: pyridine / 6.5 h

4.1: palladium 10% on activated carbon; hydrogen / acetic acid; ethyl acetate / 14 h

5.1: acetic acid / ethanol / 15 h / 20 - 50 °C

6.1: caesium carbonate / acetonitrile / 2 h

7.1: iodine; silver(I) acetate / dichloromethane / 5 h / 20 °C / Darkness

8.1: n-butyllithium; N-fluorobis(benzenesulfon)imide / tetrahydrofuran; hexane / 1 h / -78 °C

9.1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / Inert atmosphere

10.1: caesium carbonate / acetonitrile / 3 h

11.1: hydrogenchloride; water / tetrahydrofuran; methanol / 1 h / 50 °C

11.2: 20 °C

12.1: methanol; sodium hydroxide / 1 h / 50 °C

12.2: 20 °C

With pyridine; hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 5%-palladium/activated carbon; palladium 10% on activated carbon; water; hydrogen; iodine; silver(I) acetate; caesium carbonate; acetic acid; N-fluorobis(benzenesulfon)imide; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;

Reference yield:

: 848442-41-1
C₁₂H₁₇BrO₂

: 1253210-85-3
{2-fluoro-4-[(5-hydroxy-6-isopropylpyridin-2-yl)methyl]-3,5-dimethylphenoxy}acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2.83 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 11 h / 90 °C / Inert atmosphere

3.1: pyridine / 6.5 h

4.1: palladium 10% on activated carbon; hydrogen / acetic acid; ethyl acetate / 14 h

5.1: acetic acid / ethanol / 15 h / 20 - 50 °C

6.1: caesium carbonate / acetonitrile / 2 h

7.1: iodine; silver(I) acetate / dichloromethane / 5 h / 20 °C / Darkness

8.1: n-butyllithium; N-fluorobis(benzenesulfon)imide / tetrahydrofuran; hexane / 1 h / -78 °C

9.1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / Inert atmosphere

10.1: caesium carbonate / acetonitrile / 3 h

11.1: hydrogenchloride; water / tetrahydrofuran; methanol / 1 h / 50 °C

11.2: 20 °C

12.1: methanol; sodium hydroxide / 1 h / 50 °C

12.2: 20 °C

With pyridine; hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 5%-palladium/activated carbon; palladium 10% on activated carbon; water; hydrogen; iodine; silver(I) acetate; caesium carbonate; acetic acid; N-fluorobis(benzenesulfon)imide; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;