5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

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Chemical Name:5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine
CAS No.:1453207-60-7
Molecular Formula:C₂₆H₃₁F₂N₅O₃
Molecular Weight:499.561
Hs Code.:

Synonyms:5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

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Chemical Property of 5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

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Technology Process of 5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

There total 3 articles about 5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453207-83-4
5-[(2,6-difluoro-3,5-dimethoxyphenyl)ethynyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

: 1453207-60-7
5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

Guidance literature:: With palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 50 ℃; under 760.051 Torr;

Reference yield:

: 156428-85-2
3-methoxy-4-(4-methylpiperazin-1-yl)aniline

: 1453207-60-7
5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: methanesulfonic acid / isopropyl alcohol / 3 h / 130 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

3: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane; water / 8 h / 110 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; sodium acetate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2022.116657

Reference yield:

: 1453212-30-0
5-iodo-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

: 1453207-60-7
5-[2-(2,6-difluoro-3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

2: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane; water / 8 h / 110 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid hydrazide; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2022.116657