Chemical Property of PYRIMIDIN-4-YLBORONIC ACID
Chemical Property:
- Vapor Pressure:4.95E-05mmHg at 25°C
- Refractive Index:1.534
- Boiling Point:334.7 °C at 760 mmHg
- PKA:6.86±0.53(Predicted)
- Flash Point:156.2 °C
- PSA：66.24000
- Density:1.33 g/cm3
- LogP:-1.84360
- Storage Temp.:Refrigerator, under inert atmosphere
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Purity/Quality:
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99%, *data from raw suppliers
Pyrimidin-4-ylboronicAcid(~80%) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Uses
Pyrimidin-4-ylboronic Acid is an intermediate used to prepare aldosterone synthase inhibiting pyrimidinylnaphthalenes via Suzuki cross-coupling reactions. It is also used in the synthesis of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine as a potent, orally active Src kinase inhibitor with antitumor activity.
