<1R-<1α(R),3aβ,4α<(E)-(1S,3S,5R)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

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Chemical Name:<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol
CAS No.:135041-05-3
Molecular Formula:C₄₆H₇₀O₃Si₂
Molecular Weight:727.231
Hs Code.:

<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

Synonyms:<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

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Chemical Property of <1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

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Technology Process of <1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

There total 20 articles about <1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 135041-04-2
<1R-<1α(R*),3aβ,4α(1S*,3S*,5S*),7aα>>-4-<<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethynyl>octahydro-7a-methyl-1-<1,5,5-trimethyl-5-((trimethylsilyl)oxy)pentyl>-1H-inden-4-ol

: 135041-05-3
<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

Guidance literature:: With lithium aluminium tetrahydride; sodium methylate;
DOI:10.1016/S0040-4039(00)79919-9

Reference yield:

: 135040-98-1
(R)-2-<(trimethylsilyl)ethynyl>-2-cyclopenten-1-ol

: 135041-05-3
<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 67 percent / Sm, HgCl₂ / tetrahydrofuran / 31 - 40 °C

2: 82 percent / PCC / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) t-BuOK / 1.) THF, room temperature, 2 h, 2.) 30 min

4: 1.) n-BuLi / 1.) THF, hexane, 50 deg C, 15 min, 2.) -15 deg C, 20 min; 0 deg C, 30 min

5: 1.) SeO₂, t-BuOOH, 2.) LiBEt₃H / 1.) 2,2,4-trimethylpentane, 4 deg C, 20 h, 2.) THF, -50 deg C -> 0 deg C

6: 88 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

7: 88 percent / MeONa, LiAlH₄ / methanol; tetrahydrofuran / 1 h / Heating

With 1H-imidazole; tert.-butylhydroperoxide; samarium; lithium aluminium tetrahydride; n-butyllithium; selenium(IV) oxide; potassium tert-butylate; sodium methylate; lithium triethylborohydride; pyridinium chlorochromate; mercury dichloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo951229d

Reference yield:

: 135040-99-2
-1-<(trimethylsilyl)ethynyl>bicyclo<3.1.0>hexan-2-ol

: 135041-05-3
<1R-<1α(R*),3aβ,4α<(E)-(1S*,3S*,5R*)>,7aα>>-1-<1,5-dimethyl-5-<(trimethylsilyl)oxy>hexyl>-4-<2-<3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-2-methylenebicyclo<3.1.0>hexan-1-yl>ethenyl>octahydro-7a-methyl-1H-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / PCC / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) t-BuOK / 1.) THF, room temperature, 2 h, 2.) 30 min

3: 93 percent / Na₂CO₃ / methanol / 3.5 h / Ambient temperature

4: 48 percent / SeO₂, t-BuOOH / 2,2,4-trimethyl-pentane / 1.) 0 deg C, 2 h, 2.) room temperature, 4 h

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 1.) n-BuLi / 1.) THF, hexane, room temperature, 20 min, 2.) room temperature, 30 min

7: 88 percent / MeONa, LiAlH₄ / methanol; tetrahydrofuran / 1 h / Heating

With 1H-imidazole; tert.-butylhydroperoxide; lithium aluminium tetrahydride; n-butyllithium; selenium(IV) oxide; potassium tert-butylate; sodium methylate; sodium carbonate; pyridinium chlorochromate; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo951229d