6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene

Base Information

• Chemical Name: 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene
• CAS No.: 1178898-34-4
• Molecular Formula: C₂₀H₁₇Br
• Molecular Weight: 337.259
• Mol file: 1178898-34-4.mol

Synonyms:6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene

Chemical Property of 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene

There total 1 articles about 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-bromo-4,4-dimethyl-1,2,3,4-tetrahydro-1-(2-phenylethynyl)-(1H)-naphthalen-1-ol (1178898-32-2) → 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene (1178898-34-4)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 2h; Reflux;

DOI:10.1016/j.bmc.2009.05.035

Reference yield: 79.0%

Dimethyl oxalate (553-90-2) + 6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene (1178898-34-4) → methyl 2-(7,8-dihydro-8,8-dimethyl-5-(2-phenylethynyl)-naphthalen-2-yl)-2-oxoacetate (1178898-50-4)

Guidance literature:

6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

Dimethyl oxalate; In tetrahydrofuran; pentane; at -78 - 25 ℃; for 4.5h;

DOI:10.1016/j.bmc.2009.05.035

Reference yield: 71.0%

6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene (1178898-34-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 7,8-dihydro-8,8-dimethyl-5-(2-phenylethynyl)-naphthalene-2-carbaldehyde (1178898-36-6)

Guidance literature:

6-bromo-3,4-dihydro-4,4-dimethyl-1-(2-phenylethynyl)-naphthalene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; pentane; at -78 ℃; for 5h;

DOI:10.1016/j.bmc.2009.05.035

upstream raw materials:

6-bromo-4,4-dimethyl-1,2,3,4-tetrahydro-1-(2-phenylethynyl)-(1H)-naphthalen-1-ol

Downstream raw materials:

methyl 2-(7,8-dihydro-8,8-dimethyl-5-(2-phenylethynyl)-naphthalen-2-yl)-2-oxoacetate

7,8-dihydro-8,8-dimethyl-5-(2-phenylethynyl)-naphthalene-2-carbaldehyde