4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole

Base Information

• Chemical Name: 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole
• CAS No.: 110191-35-0
• Molecular Formula: C₂₃H₂₂N₂O₂
• Molecular Weight: 358.44
• Mol file: 110191-35-0.mol

Synonyms:4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole

Chemical Property of 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole

There total 4 articles about 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-methoxyphenylacetic acid (93-25-4) + 3-(benzyloxy)-6-methyl-1,2-phenylenediamine (103080-30-4) → 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole (110191-35-0)

Guidance literature:

at 120 - 130 ℃;

DOI:10.1021/jm00395a007

Reference yield:

4-methyl-2,5-dinitrophenol (68191-07-1) → 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole (110191-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / KI, K₂CO₃ / acetone / 18 h / Heating

2: 91 percent / H₂ / Raney-Ni / ethanol / 760 Torr / Ambient temperature

3: 73 percent / 120 - 130 °C

With hydrogen; potassium carbonate; potassium iodide; nickel; In ethanol; acetone;

DOI:10.1021/jm00395a007

Reference yield:

benzyl chloride (100-44-7) → 4-Benzyloxy-2-(2-methoxy-benzyl)-7-methyl-1H-benzoimidazole (110191-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / KI, K₂CO₃ / acetone / 18 h / Heating

2: 91 percent / H₂ / Raney-Ni / ethanol / 760 Torr / Ambient temperature

3: 73 percent / 120 - 130 °C

With hydrogen; potassium carbonate; potassium iodide; nickel; In ethanol; acetone;

DOI:10.1021/jm00395a007

upstream raw materials:

2-methoxyphenylacetic acid

3-(benzyloxy)-6-methyl-1,2-phenylenediamine

4-methyl-2,5-dinitrophenol

benzyl chloride

Downstream raw materials:

2-(2-Methoxy-benzyl)-7-methyl-1H-benzoimidazol-4-ol