3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt

Base Information

• Chemical Name: 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt
• CAS No.: 1354786-30-3
• Molecular Formula: C₂HF₃O₂*C₂₈H₂₄N₆O₃S₂
• Molecular Weight: 670.693
• Mol file: 1354786-30-3.mol

Synonyms:3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt

Chemical Property of 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt

There total 2 articles about 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

tert-Butyl-{[4'-{2-cyano-4-[(1,3-thiazol-2-ylamino)sulfonyl]phenoxy}-3'(1-methyl-1H-pyrazol-5-yl)biphenyl-2-yl]methyl}methylcarbamate (1354787-04-4) + trifluoroacetic acid (76-05-1) → 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt (1354786-30-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

Reference yield:

4-[4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-3-cyano-N-1,3-thiazol-2-ylbenzene sulfonamide (1235402-79-5) + (N-tert-butoxycarbonyl-N-methyl)-2-iodobenzylamine (341970-35-2) → 3-Cyano-4-({2'-[(methylamino)methyl]-3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl}oxy)-N-(1,3-thiazol-2-yl)benzenesulfonamide, trifluoroacetate salt (1354786-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis(pinacol)diborane; potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

1.2: 0.5 h / 125 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2.1: dichloromethane / 18 h / 20 °C

With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide; 1.2: Suzuki Coupling;

upstream raw materials:

tert-Butyl-{[4'-{2-cyano-4-[(1,3-thiazol-2-ylamino)sulfonyl]phenoxy}-3'(1-methyl-1H-pyrazol-5-yl)biphenyl-2-yl]methyl}methylcarbamate

trifluoroacetic acid

4-[4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-3-cyano-N-1,3-thiazol-2-ylbenzene sulfonamide

(N-tert-butoxycarbonyl-N-methyl)-2-iodobenzylamine