N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide
CAS No.:1217399-92-2
Molecular Formula:C₂₆H₃₄F₃N₃O₄
Molecular Weight:509.569
Hs Code.:

N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

Synonyms:N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

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Chemical Property of N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

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Technology Process of N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

There total 2 articles about N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140917-35-6
(R)-5-tert-butyl-2-((tetrahydrofuran-2-yl)methyl)isoxazol-3(2H)-imine

: 1217416-88-0
C₁₄H₁₅ClF₃NO₂

: 1217399-92-2
N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 50 ℃;

Reference yield:

: 556112-92-6
2-fluoro-5-trifluoromethylbenzoic acid methyl ester

: 1217399-92-2
N-[(3E)-5-tert-butyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]isoxazol-3(2H)-ylidene]-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium-t-butoxide / tetrahydrofuran / 0.5 h / 20 °C

1.2: 4 h / 20 °C

2.1: water monomer; potassium hydroxide / ethanol / 2 h / 45 °C

2.2: pH 5 / Acidic conditions

3.1: thionyl chloride / 90 °C

4.1: triethylamine / tetrahydrofuran / 20 - 50 °C

With thionyl chloride; potassium-t-butoxide; water monomer; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol;