5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid
CAS No.:1207203-74-4
Molecular Formula:C₂₁H₁₈ClFO₅S₂
Molecular Weight:468.954
Hs Code.:

Synonyms:5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

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Chemical Property of 5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

Chemical Property:

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Technology Process of 5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

There total 12 articles about 5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207203-71-1
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylthio)propoxy]phenyl}thiophene-2-carboxylic acid

: 1207203-74-4
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1207203-74-4
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: -60 - 0 °C

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C

7.1: methanol / 2 h / Reflux

8.1: triethylamine / dichloromethane / 0.25 h / 0 °C

9.1: N,N-dimethyl-formamide / 2 h / 20 °C

10.1: sodium hydroxide / water; methanol / 2 h / Reflux

11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With methanol; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 85953-29-3
methyl 2-chloro-4-fluorobenzoate

: 1207203-74-4
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(methylsulphonyl)propoxy]phenyl}thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: -60 - 0 °C

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C

7.1: methanol / 2 h / Reflux

8.1: triethylamine / dichloromethane / 0.25 h / 0 °C

9.1: N,N-dimethyl-formamide / 2 h / 20 °C

10.1: sodium hydroxide / water; methanol / 2 h / Reflux

11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With methanol; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;