16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

Base Information

Chemical Name:16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol
CAS No.:1310052-17-5
Molecular Formula:C₃₂H₄₅N₃O₂
Molecular Weight:503.728
Hs Code.:

Synonyms:16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

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Chemical Property of 16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

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Technology Process of 16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

There total 6 articles about 16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1310052-30-2
3β-acetoxy-16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol

: 1310052-17-5
16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

Guidance literature:: With methanol; potassium hydroxide; at 50 ℃; for 1h;
DOI:10.3390/molecules16064786

Reference yield:

: 2405-43-8
3β-hydroxy-16-(hydroxymethylene)androst-5-en-17-one

: 1310052-17-5
16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine

2: potassium borohydride; acetic acid / methanol; ethanol / pH 6 - 8

3: pyridine

4: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C

5: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / dichloromethane; water / 20 °C

6: methanol; potassium hydroxide / 1 h / 50 °C

With pyridine; methanol; sodium azide; copper(ll) sulfate pentahydrate; potassium borohydride; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; acetic acid; potassium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 5: Huisgen 1,3-dipolar cycloaddition;
DOI:10.3390/molecules16064786

Reference yield:

: 37492-77-6
16β-hydroxymethylandrost-5-ene-3β,17β-diol 3-acetate

: 1310052-17-5
16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-ene-3β,17β-diol

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: sodium azide / N,N-dimethyl-formamide / 6 h / 70 °C

3: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / dichloromethane; water / 20 °C

4: methanol; potassium hydroxide / 1 h / 50 °C

With pyridine; methanol; sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; potassium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; 3: Huisgen 1,3-dipolar cycloaddition;
DOI:10.3390/molecules16064786