(R)-2-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (R)-2-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 674792-04-2
• Molecular Formula: C12H24 N2 O2
• Molecular Weight: 228.335
• Hs Code.: 2933599090
• Mol file: 674792-04-2.mol

Synonyms:(R)-1-Boc-2-isopropyl-piperazine;(R)-1-Boc- 2-isopropyl-piperazine;(R)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester;(2r)-1-n-boc-2-isopropylpiperazine;(R)-2-isopropyl-piperazine-1-carboxylic acid tert-butyl ester;

Chemical Property of (R)-2-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 298.4 °C at 760 mmHg
• PKA: 8.41±0.40(Predicted)
• Flash Point: 134.2 °C
• PSA: 41.57000
• Density: 0.98 g/cm³
• LogP: 2.11800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-Butyl2-isopropylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 5 articles about (R)-2-ISOPROPYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H30N2O2 (674791-98-1) → (R)-tert-butyl 2-isopropylpiperazine-1-carboxylate (674792-04-2,886766-25-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

C14H20N2O (674791-88-9) → (R)-tert-butyl 2-isopropylpiperazine-1-carboxylate (674792-04-2,886766-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Heating / reflux

1.2: 1 h / 20 °C

2.1: dichloromethane / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With lithium aluminium tetrahydride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

C20H30N2O4 (674791-86-7) → (R)-tert-butyl 2-isopropylpiperazine-1-carboxylate (674792-04-2,886766-25-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Heating / reflux

2.2: 1 h / 20 °C

3.1: dichloromethane / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

With lithium aluminium tetrahydride; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

C₁₉H₃₀N₂O₂

C₁₄H₂₀N₂O

C₂₀H₃₀N₂O₄

di-tert-butyl dicarbonate

Refernces