2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile
• CAS No.: 1373941-14-0
• Molecular Formula: C₂₂H₁₈N₄O₂S
• Molecular Weight: 402.477
• Mol file: 1373941-14-0.mol

Synonyms:2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile

Chemical Property of 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile

There total 3 articles about 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + para-thiocresol (106-45-6) + malononitrile (109-77-3) → 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile (1373941-14-0)

Guidance literature:

With propylphosphonium hydrogen carbonateionic liquid supported on nano-silica; In neat (no solvent); at 50 ℃; for 0.333333h; Reagent/catalyst; Temperature;

DOI:10.1039/c5ra03569d

Reference yield:

C22H20N4O2S → 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile (1373941-14-0)

Guidance literature:

With potassium permanganate; In ethanol; water; for 0.583333h; Reflux;

DOI:10.1080/00397911.2011.555284

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) + para-thiocresol (106-45-6) → 2-amino-4-(3,4-dimethoxyphenyl)-6-(4-methylphenylsulfanyl)-pyridine-3,5-dicarbonitrile (1373941-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol; water / 0.42 h / Reflux

2: potassium permanganate / ethanol; water / 0.58 h / Reflux

With potassium permanganate; potassium carbonate; In ethanol; water;

DOI:10.1080/00397911.2011.555284

upstream raw materials:

3,4-dimethoxy-benzaldehyde

para-thiocresol

malononitrile