(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

Base Information

Chemical Name:(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol
CAS No.:1429199-26-7
Molecular Formula:C₁₄H₁₇F₃N₂O₃S
Molecular Weight:350.362
Hs Code.:

Synonyms:(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

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Chemical Property of (7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

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Technology Process of (7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

There total 6 articles about (7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1429200-47-4,1161000-19-6
(7S,8aR)-octahydropyrrolo[1,2-a]pyrazin-7-ol

: 1429199-26-7
(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 481704-21-6
(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

: 1429199-26-7
(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 3 h / Reflux

2: triethylamine / 2-ethoxy-ethanol / 20 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4: hydrogen; 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 16 h / 50 °C / 1551.49 Torr

5: triethylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; 2,2,2-trifluoroethanol; benzene;

Reference yield:

: 142347-81-7,441067-49-8
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

: 1429199-26-7
(7S,8aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]-pyrazin-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 4 h / 0 - 25 °C

2: benzene / 3 h / Reflux

3: triethylamine / 2-ethoxy-ethanol / 20 h / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

5: hydrogen; 20% palladium hydroxide-activated charcoal / 2,2,2-trifluoroethanol / 16 h / 50 °C / 1551.49 Torr

6: triethylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; dichloromethane; 2,2,2-trifluoroethanol; benzene;