(E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester

Base Information

• Chemical Name: (E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester
• CAS No.: 327989-71-9
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.297

Synonyms:(E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester

Chemical Property of (E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester

There total 1 articles about (E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → (E)-Nα-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester (327989-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 17.7 g / triethylamine / dimethylformamide / 1.5 h / 55 °C

2: 90 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH₂Cl₂ / 3.5 h / 35 °C

3: lithium hexamethyldisilazide / tetrahydrofuran / 0.92 h / 0 - 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Horner-Wadsworth-Emmons reaction;

DOI:10.1016/j.tetlet.2005.05.093

Reference yield:

(E)-Nα-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester (327989-71-9) → (2S,4S)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid (147235-94-7,168034-53-5,168034-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.19 g / H₂ / PdCl₂ / methanol / 24 h / 2327.17 Torr

2: 1N NaOH / 2.5 h / Heating

3: CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; hydrogen; palladium dichloride; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2005.05.093

upstream raw materials:

L-4-hydroxyproline methyl ester hydrochloride

Downstream raw materials:

(2S,4S)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 327989-71-9 (E)-N^α-(1,1-dimethylethoxycarbonyl)-4-(2-cyanomethylene)-L-proline methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send