1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Base Information

Chemical Name:1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate
CAS No.:1570494-06-2
Molecular Formula:C₂HF₃O₂*C₂₄H₂₄F₃N₇O₂
Molecular Weight:613.519
Hs Code.:

Synonyms:1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

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Chemical Property of 1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

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Technology Process of 1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

There total 4 articles about 1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.1%

: 109-01-3
1-methyl-piperazine

: 1570494-16-4
2-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

: 76-05-1
trifluoroacetic acid

: 1570494-06-2
1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: 1-methyl-piperazine; 2-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole; With sodium t-butanolate; ruphos; In tetrahydrofuran; at 65 ℃; for 2h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 1570494-06-2
1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 18 h / 50 °C

2.1: triethylamine; hydrazine hydrate / methanol / 20 °C

3.1: trichlorophosphate / 2.5 h / 100 °C

4.1: sodium t-butanolate; ruphos / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

4.2: Waters C₁₈

With potassium carbonate; hydrazine hydrate; triethylamine; sodium t-butanolate; trichlorophosphate; ruphos; In tetrahydrofuran; methanol;

Reference yield:

: 1570494-13-1
1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carbohydrazide

: 1570494-06-2
1-methyl-4-(3-((5-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)-1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 2.5 h / 100 °C

2.1: sodium t-butanolate; ruphos / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2.2: Waters C₁₈

With sodium t-butanolate; trichlorophosphate; ruphos; In tetrahydrofuran;