4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid

Base Information

Chemical Name:4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid
CAS No.:1005786-00-4
Molecular Formula:C₁₇H₂₈O₃Si
Molecular Weight:308.493
Hs Code.:
Mol file:1005786-00-4.mol

Synonyms:4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoic acid

Suppliers and Price of 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[1-[tert-Butyl(dimethyl)silyl]oxy-2-methylpropan-2-yl]benzoicAcid
10mg
$ 45.00

Crysdot
4-(1-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-2-yl)benzoicacid 95+%
1g
$ 594.00

Crysdot
4-(1-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-2-yl)benzoicacid 95+%
5g
$ 1786.00

Chemenu
4-(1-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-2-yl)benzoicacid 95%
5g
$ 1683.00

Chemenu
4-(1-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-2-yl)benzoicacid 95%
1g
$ 561.00

AK Scientific
4-[1-[tert-butyl(dimethyl)silyl]oxy-2-methylpropan-2-yl]benzoicacid
250mg
$ 354.80

Total 2 raw suppliers

Chemical Property of 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-[1-[tert-Butyl(dimethyl)silyl]oxy-2-methylpropan-2-yl]benzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-[1-[tert-Butyl(dimethyl)silyl]oxy-2-methylpropan-2-yl]benzoic Acid is used as a reactant in the preparation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.

Technology Process of 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid

There total 3 articles about 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1005785-98-7
ethyl 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoate

: 1005786-00-4
4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoic acid

Guidance literature:: ethyl 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoate; With water; potassium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; Inert atmosphere;

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 1005786-00-4
4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; palladium diacetate; tri-tert-butyl phosphine / 1,4-dioxane / 4 h / 110 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

3: 2,6-dimethylpyridine / dichloromethane / 1 h / 5 - 20 °C

4: potassium hydroxide / water; methanol; tetrahydrofuran / 1 h / 70 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; tri-tert-butyl phosphine; palladium diacetate; caesium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.10.084

Reference yield:

: 1005785-96-5
ethyl 4-(1-hydroxy-2-methylpropan-2-yl)benzoate

: 1005786-00-4
4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 1 h / 5 - 20 °C

3: potassium hydroxide / water; methanol; tetrahydrofuran / 1 h / 70 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.10.084