4-(10-hydroxydecyloxy)phenyl isonicotinate

Base Information

• Chemical Name: 4-(10-hydroxydecyloxy)phenyl isonicotinate
• CAS No.: 1429770-64-8
• Molecular Formula: C₂₂H₂₉NO₄
• Molecular Weight: 371.477
• Mol file: 1429770-64-8.mol

Synonyms:4-(10-hydroxydecyloxy)phenyl isonicotinate

Chemical Property of 4-(10-hydroxydecyloxy)phenyl isonicotinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(10-hydroxydecyloxy)phenyl isonicotinate

There total 3 articles about 4-(10-hydroxydecyloxy)phenyl isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

4-(10-hydroxydecyloxy)phenol (1429770-63-7) + isonicotinoyl chloride hydrochloride (39178-35-3) → 4-(10-hydroxydecyloxy)phenyl isonicotinate (1429770-64-8)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1016/j.jorganchem.2012.10.016

Reference yield:

1,10-Decanediol (112-47-0) → 4-(10-hydroxydecyloxy)phenyl isonicotinate (1429770-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen bromide / ligroin / 72 h

2.1: potassium carbonate; 18-crown-6 ether / acetone / 0.5 h / 20 °C / Inert atmosphere

2.2: 96 h / Reflux; Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C / 3000.3 Torr

4.1: triethylamine / chloroform / 20 °C

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen bromide; hydrogen; potassium carbonate; triethylamine; In ligroin; ethanol; dichloromethane; chloroform; acetone;

DOI:10.1016/j.jorganchem.2012.10.016

Reference yield:

1-bromo-10-decanol (53463-68-6) → 4-(10-hydroxydecyloxy)phenyl isonicotinate (1429770-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / acetone / 0.5 h / 20 °C / Inert atmosphere

1.2: 96 h / Reflux; Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / dichloromethane; ethanol / 20 °C / 3000.3 Torr

3.1: triethylamine / chloroform / 20 °C

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In ethanol; dichloromethane; chloroform; acetone;

DOI:10.1016/j.jorganchem.2012.10.016

upstream raw materials:

4-(10-hydroxydecyloxy)phenol

isonicotinoyl chloride hydrochloride

1,10-Decanediol

1-bromo-10-decanol

Downstream raw materials:

C₂₈H₃₅Cl₂NO₄Ru

C₃₂H₄₃Cl₂NO₄Ru

C₃₄H₄₇Cl₂NO₄Ru