N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

Base Information

Chemical Name:N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine
CAS No.:1201790-07-9
Molecular Formula:C₂₆H₂₅N₅O
Molecular Weight:423.517
Hs Code.:

Synonyms:N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

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Chemical Property of N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

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Technology Process of N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

There total 3 articles about N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 627899-90-5
N,N-dimethyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-1-amine

: 1201786-91-5
3-bromo-6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201790-07-9
N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 105 ℃; for 23h; Inert atmosphere; Sealed tube;

Reference yield:

: 1201786-75-5
C₁₅H₁₁ClN₄

: 1201790-07-9
N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / palladium diacetate; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 1,4-dioxane / 100 °C / Inert atmosphere

2: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 23 h / 105 °C / Inert atmosphere; Sealed tube

With potassium tert-butylate; bromine; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Hartwig-Buchwald reaction;

Reference yield:

: 1201786-83-5
6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201790-07-9
N,N-dimethyl-3-{4-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]phenoxy}propan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 23 h / 105 °C / Inert atmosphere; Sealed tube

With bromine; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;