3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

Base Information

Chemical Name:3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt
CAS No.:671777-24-5
Molecular Formula:C₂H₄O₂*C₂₉H₃₉N₃O₆
Molecular Weight:585.698
Hs Code.:

Synonyms:3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

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Chemical Property of 3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

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Technology Process of 3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

There total 10 articles about 3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(3-{4-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]butyl}phenyl)dihydropyrimidine-2,4(1H,3H)-dione

: 671777-24-5
3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

Guidance literature:: With water; acetic acid; at 70 ℃; for 0.75h;

Reference yield:

: 671777-45-0
3-(3-{4[(6-bromohexyl)oxy]but-1-ynyl}phenyl)-6-chloropyrimidine-2,4(1H,3H)-dione

: 671777-24-5
3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide

2: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

3: water / 75 °C

With platinum(IV) oxide; hydrogen; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.064

Reference yield:

: 671777-44-9
6-CHLORO-3-(3-IODOPHENVL) PVRIMIDINE-2, 4 (1H, 3H)-DIONE

: 671777-24-5
3-[3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)phenyl]-2,4(1H,3H)-pyrimidinedione acetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: N,N-dimethyl-formamide

3: platinum(IV) oxide; hydrogen / ethyl acetate / Enzymatic reaction

4: water / 75 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1016/j.bmc.2011.05.064