(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

Base Information

Chemical Name:(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime
CAS No.:656830-84-1
Molecular Formula:C₁₆H₂₁N₅O₃
Molecular Weight:331.374
Hs Code.:

Synonyms:(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

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Chemical Property of (1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

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Technology Process of (1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

There total 7 articles about (1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 656830-82-9
2,6-diamino-5-[4-(benzyloxy)-1-(nitromethyl)butyl]pyrimidin-4(3H)-one

: 656830-84-1
(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

Guidance literature:: With thiophenol; triethylamine; tin(ll) chloride; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1039/b309779j

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 656830-84-1
(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / aq. NaOH / ethanol / 3 h / 0 °C

2: CH₂Cl₂ / 0 °C

3: 18.87 g / Et₃N / CH₂Cl₂ / 10 h / 0 °C

4: 81 percent / ethyl acetate; H₂O / 18 h / 20 °C

5: 65 percent / benzenethiol; SnCl₂; Et₃N / acetonitrile / 1 h / 20 °C

With sodium hydroxide; thiophenol; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 4: Michael addition;
DOI:10.1039/b309779j

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 656830-84-1
(1E)-5-(benzyloxy)-2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)pentanal oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / 20 °C

2: 69 percent / aq. NaOH / ethanol / 3 h / 0 °C

3: CH₂Cl₂ / 0 °C

4: 18.87 g / Et₃N / CH₂Cl₂ / 10 h / 0 °C

5: 81 percent / ethyl acetate; H₂O / 18 h / 20 °C

6: 65 percent / benzenethiol; SnCl₂; Et₃N / acetonitrile / 1 h / 20 °C

With sodium hydroxide; thiophenol; triethylamine; pyridinium chlorochromate; tin(ll) chloride; In ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 5: Michael addition;
DOI:10.1039/b309779j