3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Base Information

Chemical Name:3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine
CAS No.:1308869-13-7
Molecular Formula:C₂₅H₂₅N₃
Molecular Weight:367.494
Hs Code.:

Synonyms:3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

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Chemical Property of 3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

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Technology Process of 3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

There total 10 articles about 3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₁₉N₃

: 1308869-13-7
3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1308869-13-7
3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate / Cooling with ice; Sealed tube; Inert atmosphere

1.2: 48.5 h / 75 °C

1.3: Cooling with ice

2.1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C

3.1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 2 h / Reflux

4.1: thionyl chloride / dichloromethane / 0.25 h / 20 °C

5.1: toluene / 64 h / 20 °C / Reflux

6.1: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C

7.1: 1-methyl-pyrrolidin-2-one / 1.17 h / 200 °C

8.1: trifluoroacetic acid / 1 h / 90 °C

9.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere; Sealed vessel

9.2: 1 h / 50 °C

10.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol

With sodium tetrahydroborate; thionyl chloride; ethanol; hydrogen; potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

Reference yield:

: C₃₁H₂₆BrN₃O

: 1308869-13-7
3-(2-(5-ethylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 1 h / 90 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere; Sealed vessel

2.2: 1 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol

With hydrogen; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;