1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride

Base Information

• Chemical Name: 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride
• CAS No.: 923571-16-8
• Molecular Formula: C₂₄H₂₂NO₄*Cl
• Molecular Weight: 423.896
• Mol file: 923571-16-8.mol

Synonyms:1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride

Chemical Property of 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride

Chemical Property:

Purity/Quality:

99.0% Min ^*data from raw suppliers

4-?[(2,?3-?Dihydro-?5,?6-?dimethoxy-?1-?oxo-?1H-?inden-?2-?yl)?carbonyl]?-?1-?(phenylmethyl)?-pyridiniumChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-?[(2,?3-?Dihydro-?5,?6-?dimethoxy-?1-?oxo-?1H-?inden-?2-?yl)?carbonyl]?-?1-?(phenylmethyl)?-pyridinium Chloride is an impurity in the synthesis of Donepezi (D531750), A nootropic. An inhibitor of acetylcholinesterase.

Technology Process of 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride

There total 1 articles about 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5,6-dimethoxy-2-(pyridine-4-carbonyl)indan-1-one (923571-15-7) + benzyl chloride (100-44-7) → 1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride (923571-16-8)

Guidance literature:

at 177 ℃; for 1h; Product distribution / selectivity; Heating / reflux;

Reference yield:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride (923571-16-8) → 2-((1-benzyl-piperidin-4-yl)-hydroxymethyl)-5,6-dimethoxyindan-1-one (197010-20-1)

Guidance literature:

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride; With hydrogen; platinum on activated charcoal; In methanol; at 20 ℃; under 3750.38 - 4500.45 Torr;

With sodium hydrogencarbonate; In methanol; water; Product distribution / selectivity;

upstream raw materials:

5,6-dimethoxy-2-(pyridine-4-carbonyl)indan-1-one

benzyl chloride

Downstream raw materials:

2-((1-benzyl-piperidin-4-yl)-hydroxymethyl)-5,6-dimethoxyindan-1-one

Refernces