3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

Base Information

Chemical Name:3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one
CAS No.:218145-18-7
Molecular Formula:C₃₆H₂₉F₄N₃O₇
Molecular Weight:691.636
Hs Code.:

3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

Synonyms:3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

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Chemical Property of 3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

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Technology Process of 3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

There total 4 articles about 3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 218145-17-6
5,6,7,8-Tetrafluoro-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

: 218145-18-7
3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1016/S0040-4039(98)01932-7

Reference yield:

: 1022-79-3
5-bromo-2'-deoxycytidine

: 218145-18-7
3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂O, N,N-diisopropylethylamine

2: 40 percent / K₂CO₃ / dimethylsulfoxide / 50 °C

3: 52 percent / pyridine / Ambient temperature

With pyridine; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)01932-7

Reference yield:

: 3992-42-5
2'-deoxycytidine monohydrochloride

: 218145-18-7
3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5,6,7,8-tetrafluoro-3H,9H-10-oxa-1,3,9-triaza-anthracen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: Br₂ / H₂O / Ambient temperature

2: H₂O, N,N-diisopropylethylamine

3: 40 percent / K₂CO₃ / dimethylsulfoxide / 50 °C

4: 52 percent / pyridine / Ambient temperature

With pyridine; water; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)01932-7