(1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

Base Information

• Chemical Name: (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione
• CAS No.: 894430-57-0
• Molecular Formula: C₃₂H₃₃N₃O₇
• Molecular Weight: 571.63

Synonyms:(1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

Chemical Property of (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

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Technology Process of (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

There total 5 articles about (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(1R,6R,7S,8S,10S,11R,12S)-11-benzyloxy-10-(4,4'-dimethoxytrityloxymethyl)-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.02,7.08,12]tridecan-3,5-dione (894430-56-9) → (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.02,7.08,12]tridecan-3,5-dione (894430-57-0)

Guidance literature:

With ammonium formate; palladium dihydroxide; In ethyl acetate; at 50 ℃; for 40h;

DOI:10.1021/jo060331f

Reference yield:

(1S,3R,4S,7R)-7-benzyloxy-1-methanesulfonoxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane (894430-43-4) → (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.02,7.08,12]tridecan-3,5-dione (894430-57-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 32 percent / 18-crown-6 / dioxane / Heating

2: 60 percent / NH₃ / methanol / 14 h / 20 °C

3: 82 percent / DMAP; pyridine / 21 h / 20 °C

4: 66 percent / ammonium formate / Pd(OH)2/C / ethyl acetate / 40 h / 50 °C

With pyridine; dmap; 18-crown-6 ether; ammonia; ammonium formate; palladium dihydroxide; In 1,4-dioxane; methanol; ethyl acetate;

DOI:10.1021/jo060331f

Reference yield:

(1R,6R,7S,8S,10S,11R,12S)-10-acetoxymethyl-11-benzyloxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.02,7.08,12]tridecan-3,5-dione (894430-51-4) → (1R,6R,7S,8S,10S,11R,12S)-10-(4,4'-dimethoxytrityloxymethyl)-11-hydroxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.02,7.08,12]tridecan-3,5-dione (894430-57-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / NH₃ / methanol / 14 h / 20 °C

2: 82 percent / DMAP; pyridine / 21 h / 20 °C

3: 66 percent / ammonium formate / Pd(OH)2/C / ethyl acetate / 40 h / 50 °C

With pyridine; dmap; ammonia; ammonium formate; palladium dihydroxide; In methanol; ethyl acetate;

DOI:10.1021/jo060331f

upstream raw materials:

(1R,6R,7S,8S,10S,11R,12S)-11-benzyloxy-10-(4,4'-dimethoxytrityloxymethyl)-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

(1R,6R,7S,8S,10S,11R,12S)-10-acetoxymethyl-11-benzyloxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione

(1S,3R,4S,7R)-7-benzyloxy-1-methanesulfonoxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

4,4'-dimethoxytrityl chloride

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