1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:1312600-18-2
Molecular Formula:C₂₁H₂₃N₇O₂S
Molecular Weight:437.525
Hs Code.:

Synonyms:1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

: 1312600-18-2
1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With sodium hydroxide; In water; pH=13;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1312600-18-2
1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 72 h / 20 °C / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 1 h / 125 °C

4.2: 0.17 h / 20 °C / Inert atmosphere

4.3: 1.5 h / 40 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

6.1: sodium hydroxide / water / pH 13

With hydrogenchloride; sodium azide; sodium methylate; potassium carbonate; ammonium chloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1312600-36-4
tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate

: 1312600-18-2
1-[(2-ethyl-2H-tetrazol-5-yl)methyl]-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 1 h / 125 °C

2.2: 0.17 h / 20 °C / Inert atmosphere

2.3: 1.5 h / 40 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: sodium hydroxide / water / pH 13

With hydrogenchloride; sodium azide; potassium carbonate; ammonium chloride; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;