2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Base Information

Chemical Name:2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide
CAS No.:1334675-29-4
Molecular Formula:C₂₉H₃₈N₆O₆Si
Molecular Weight:594.743
Hs Code.:

2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Synonyms:2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

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Chemical Property of 2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

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Technology Process of 2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

There total 4 articles about 2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1184926-29-1
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

: 1334675-00-1
(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl-ammonium trifluoroacetate

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1334675-29-4
2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Guidance literature:: 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine; With Vilsmeier reagent; In chloroform; at 20 ℃; for 8h; Reflux; Inert atmosphere;

With sodium hydrogencarbonate; In chloroform;

(R)-2-(3-cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl-ammonium trifluoroacetate; 3,4,5-trimethoxyphenylboronic Acid;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1334675-29-4
2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: Vilsmeier reagent / chloroform / 8 h / 20 °C / Reflux; Inert atmosphere

With Vilsmeier reagent; sodium hydride; In chloroform; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1334675-29-4
2-(3,4,5-trimethoxyphenyl)-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxoethyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 0 - 20 °C

2.1: Vilsmeier reagent / chloroform / 8 h / 20 °C / Reflux; Inert atmosphere

With Vilsmeier reagent; sodium hydride; In chloroform; N,N-dimethyl-formamide; mineral oil;