(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

Base Information

Chemical Name:(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide
CAS No.:1262760-18-8
Molecular Formula:C₂₂H₂₄F₃IN₂O₅S
Molecular Weight:612.409
Hs Code.:

Synonyms:(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

There total 13 articles about (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 923032-74-0
3,4-difluoro-N₂-(2-fluoro-4-iodo-phenyl)-6-methoxy-benzene-1,2-diamine

: 1415503-36-4
1-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}cyclopropanesulfonyl bromide

: 1262760-18-8
(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

Guidance literature:: With pyridine; sulfolane; at 23 ℃; for 18h;

Reference yield: 92.2%

: 923032-74-0
3,4-difluoro-N₂-(2-fluoro-4-iodo-phenyl)-6-methoxy-benzene-1,2-diamine

: 1262760-00-8
(S)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonyl chloride

: 1262760-18-8
(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

Guidance literature:: With pyridine; sulfolane; tetrabutylammomium bromide; at 70 ℃; for 18h;

Reference yield:

: 1262760-32-6
1,2-bis(1-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropyl)disulfane

: 1262760-18-8
(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)cyclopropane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide; hydrogenchloride / acetonitrile; water / 0.33 h / 10 - 20 °C

2: pyridine / 20 °C

With pyridine; hydrogenchloride; N-chloro-succinimide; In water; acetonitrile;