5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

Base Information

Chemical Name:5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine
CAS No.:1453207-65-2
Molecular Formula:C₂₅H₂₈Cl₂N₄O₄
Molecular Weight:519.428
Hs Code.:

Synonyms:5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

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Chemical Property of 5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

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Technology Process of 5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

There total 4 articles about 5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453211-64-7
tert-butyl 4-[4-({5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-3-methoxyphenyl]piperidine-1-carboxylate

: 1453207-65-2
5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 4h; Cooling with ice;

Reference yield:

: 1453211-58-9
2-chloro-5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]pyrimidine

: 1453207-65-2
5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 3 h / 20 - 100 °C / Inert atmosphere

2: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1,4-dioxane; chloroform;

Reference yield:

: 877-88-3
3,5-dimethoxybenzyl bromide

: 1453207-65-2
5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]-N-[2-methoxy-4-(piperidin-4-yl)phenyl]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 20 °C / Cooling with ice

2: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 20 - 60 °C

3: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / 3 h / 20 - 100 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

With N-chloro-succinimide; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;