C₁₈H₁₆F₃NO₃

Base Information

Chemical Name:C₁₈H₁₆F₃NO₃
CAS No.:1301173-23-8
Molecular Formula:C₁₈H₁₆F₃NO₃
Molecular Weight:351.325
Hs Code.:

C<sub>18</sub>H<sub>16</sub>F<sub>3</sub>NO<sub>3</sub>

Synonyms:C₁₈H₁₆F₃NO₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₆F₃NO₃

Chemical Property:

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Technology Process of C₁₈H₁₆F₃NO₃

There total 4 articles about C₁₈H₁₆F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301173-22-7
C₁₄H₁₀F₃NO₂

: 6148-64-7
ethyl potassium malonate

: 1301173-23-8
C₁₈H₁₆F₃NO₃

Guidance literature:: C₁₄H₁₀F₃NO₂; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; Cooling with salt-ice; Cooling with ice;

ethyl potassium malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; at 20 ℃; Cooling with ice; Cooling with salt-ice;

Reference yield:

: 1186309-52-3
1,3-diethyl 2-(5-fluoropyridin-2-yl)propanedioate

: 1301173-23-8
C₁₈H₁₆F₃NO₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 50 - 60 °C

2.1: sodium hydroxide; water / 1 h / 100 °C

2.2: pH ~ 1 / Cooling with ice

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Cooling with salt-ice; Cooling with ice

3.2: 20 °C / Cooling with ice; Cooling with salt-ice

With water; sodium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1301173-23-8
C₁₈H₁₆F₃NO₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; copper(l) iodide; 2-Picolinic acid / 1,4-dioxane / 100 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 50 - 60 °C

3.1: sodium hydroxide; water / 1 h / 100 °C

3.2: pH ~ 1 / Cooling with ice

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Cooling with salt-ice; Cooling with ice

4.2: 20 °C / Cooling with ice; Cooling with salt-ice

With 2-Picolinic acid; copper(l) iodide; water; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;