PPADS TETRASODIUM SALT

Base Information

• Chemical Name: PPADS TETRASODIUM SALT
• CAS No.: 192575-19-2
• Molecular Formula: C14H14 N3 O12 P S2 . 4 Na
• Molecular Weight: 599.3
• Mol file: 192575-19-2.mol

Synonyms:1,3-Benzenedisulfonicacid,4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-,tetrasodium salt (9CI); PPADS tetrasodium

Chemical Property of PPADS TETRASODIUM SALT

Chemical Property:

• PSA: 288.30000
• LogP: 3.77900
• Storage Temp.: −20°C
• Solubility.: H2O: >10 mg/mL

Purity/Quality:

99% ^*data from raw suppliers

PPADS Tetrasodium ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease . P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats. PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease.