2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

Base Information

Chemical Name:2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide
CAS No.:174355-83-0
Molecular Formula:C₃₄H₄₁Br₂N₇O
Molecular Weight:723.554
Hs Code.:

Synonyms:2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

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Chemical Property of 2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

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Technology Process of 2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

There total 11 articles about 2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 174355-89-6
2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(4-tert-butyl-benzyl)-N-(3-hydroxymethyl-phenyl)-benzamide

: 174355-83-0
2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

Guidance literature:: With pyridine; phosphorus tribromide; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jo951098g

Reference yield:

: 147355-04-2
5-bromo-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)benzoic acid

: 174355-83-0
2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / CH₂Cl₂; toluene / 2 h / Ambient temperature

3: 100 percent / NH₂NH₂ / methanol / 6 h / Heating

4: 1.) i-Pr₂NEt, 2.) NH₃ / 1.) THF, 0 deg C, 1.5 h, 2.) 1.5 h

5: 99 percent / i-Pr₂NEt / tetrahydrofuran / 10 h / Heating

6: 84 percent / HOAc, H₂O / tetrahydrofuran / 72 h / Ambient temperature

7: 92 percent / PBr₃, pyridine / tetrahydrofuran / 1 h / 0 °C

With pyridine; thionyl chloride; ammonia; water; phosphorus tribromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo951098g

Reference yield:

: 1877-77-6
3-aminobenzenemethanol

: 174355-83-0
2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / imidazole / dimethylformamide / 10 h / Ambient temperature

2: 50 percent / Et₃N / tetrahydrofuran / 4 h / Heating

3: Et₃N / CH₂Cl₂; toluene / 2 h / Ambient temperature

4: 100 percent / NH₂NH₂ / methanol / 6 h / Heating

5: 1.) i-Pr₂NEt, 2.) NH₃ / 1.) THF, 0 deg C, 1.5 h, 2.) 1.5 h

6: 99 percent / i-Pr₂NEt / tetrahydrofuran / 10 h / Heating

7: 84 percent / HOAc, H₂O / tetrahydrofuran / 72 h / Ambient temperature

8: 92 percent / PBr₃, pyridine / tetrahydrofuran / 1 h / 0 °C

With pyridine; 1H-imidazole; ammonia; water; phosphorus tribromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo951098g