(E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate

Base Information

• Chemical Name: (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate
• CAS No.: 1353046-54-4
• Molecular Formula: C₂₈H₃₃BrN₄O₂
• Molecular Weight: 537.5
• Mol file: 1353046-54-4.mol

Synonyms:(E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate

Chemical Property of (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate

There total 3 articles about (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-3-azido-1-bromo-2-methylprop-1-ene (959126-16-0) + ethyl 2-(diphenylmethyleneamino)non-8-ynoate (1353046-53-3) → (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate (1353046-54-4)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol; at 20 ℃; for 12h;

DOI:10.1002/cmdc.201100316

Reference yield:

ethyl N-diphenylmethylene glycine (69555-14-2) → (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate (1353046-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 69 h / 0 - 20 °C

2.1: copper(II) sulfate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 12 h / 20 °C

With potassium tert-butylate; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/cmdc.201100316

Reference yield:

1-iodo-6-heptyne (87462-66-6) → (E)-ethyl 7-[1-(3-bromo-2-methylallyl)-1H-1,2,3-triazol-4-yl]-2-(diphenylmethyleneamino)heptanoate (1353046-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 69 h / 0 - 20 °C

2.1: copper(II) sulfate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 12 h / 20 °C

With potassium tert-butylate; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/cmdc.201100316

upstream raw materials:

(E)-3-azido-1-bromo-2-methylprop-1-ene

ethyl 2-(diphenylmethyleneamino)non-8-ynoate

ethyl N-diphenylmethylene glycine

1-iodo-6-heptyne

Downstream raw materials:

C₄₁H₄₄N₄O

C₃₈H₃₆F₂N₄O

C₄₃H₄₇N₅O

C₃₉H₃₈N₄O₃