biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Base Information

• Chemical Name: biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide
• CAS No.: 186550-30-1
• Molecular Formula: C₂₄H₂₁N₃O₃S
• Molecular Weight: 431.515

Synonyms:biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Chemical Property of biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

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Technology Process of biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

There total 2 articles about biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-diphenylsulfonyl chloride (1623-93-4) + 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride → biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (186550-30-1)

Guidance literature:

With triethylamine; In acetonitrile; for 4h;

DOI:10.1021/jm990041+

Reference yield:

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester (186550-17-4) → biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (186550-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 7.3 g / HCl / ethyl acetate / 4 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate; 1: acidolysis / 2: Condensation;

DOI:10.1021/jm990040h

Reference yield:

biphenyl-4-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (186550-30-1) → 3-[(S)-3-(Biphenyl-4-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzimidoyl chloride

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/jm990040h

upstream raw materials:

4-diphenylsulfonyl chloride

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester

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