1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Base Information

Chemical Name:1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one
CAS No.:727375-71-5
Molecular Formula:C₂₃H₂₃BrF₃NO₃
Molecular Weight:498.34
Hs Code.:

Synonyms:1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Suppliers and Price of 1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

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Chemical Property of 1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

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Technology Process of 1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

There total 1 articles about 1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1055934-95-6
2-[2-(5-bromo-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

: 611-36-9
quinolin-4-ol

: 727375-71-5
1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Guidance literature:: With sodium ethanolate; In ethanol; at 85 ℃; for 14h;

Reference yield: 30.0%

: 6165-69-1
Thien-3-ylboronic acid

: 727375-71-5
1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

: 1-[2-hydroxy-4-(2-methoxy-5-thiophen-3-ylphenyl)-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Guidance literature:: Thien-3-ylboronic acid; 1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one; With sodium carbonate; In methanol; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; for 0.166667h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield: 27.0%

: 727375-71-5
1-[4-(5-bromo-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

: 111-34-2,92680-80-3
-butyl vinyl ether

: 727375-77-1
1-[4-(5-acetyl-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; potassium carbonate; palladium diacetate; In DMF (N,N-dimethyl-formamide); water; at 122 ℃; for 1h; Microwave irradiation;