(3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

Base Information

• Chemical Name: (3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one
• CAS No.: 1258948-55-8
• Molecular Formula: C₂₈H₃₇NO₄S₃
• Molecular Weight: 547.804

Synonyms:(3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

Chemical Property of (3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

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Technology Process of (3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

There total 1 articles about (3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3R,5S)-3-[2-(2-benzyl-1,3-dithian-2-yl)acetyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one (1258948-54-7) → (3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one (1258948-55-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201000914

Reference yield: 87.0%

(3R,5S,1S)-3-[2-(2-benzyl-1,3-dithian-2-yl)-1-hydroxyethyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one (1258948-55-8) → (3R,5S,1S)-3-(1-hydroxy-3-oxo-4-phenylbutyl)-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one (1258948-56-9)

Guidance literature:

With iodine; sodium hydrogencarbonate; In water; acetone; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000914

upstream raw materials:

(3R,5S)-3-[2-(2-benzyl-1,3-dithian-2-yl)acetyl]-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

Downstream raw materials:

(3R,5S,1S)-3-(1-hydroxy-3-oxo-4-phenylbutyl)-5-isobutyl-1-(toluene-4-sulfonyl)pyrrolidin-2-one

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