7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

Base Information

Chemical Name:7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid
CAS No.:125442-85-5
Molecular Formula:C₂₀H₁₈Cl₂F₂O₅
Molecular Weight:447.263
Hs Code.:

Synonyms:7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

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Technology Process of 7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

There total 6 articles about 7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 125442-95-7
7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid ethyl ester

: 125442-85-5
7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

Guidance literature:: With sodium hydroxide; oxonium; water; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 125442-89-9
1-Benzyloxy-2-bromomethyl-3,5-dichloro-benzene

: 125442-85-5
7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / KH / dimethylformamide; benzene

2: 95 percent / NBS, H₂O / acetone

3: 33 percent / diethylaminosulfur trifluoride (DAST) / neat (no solvent) / 60 °C

4: 99 percent / H₃O⁽¹⁺⁾ / tetrahydrofuran / -78 °C

5: 20 percent / 1.) LiN(TMS)2; 2.) H₃O⁽¹⁺⁾ / tetrahydrofuran / -78 °C

6: 99 percent / 1.) NaOH, H₂O; 2.) H₃O⁽¹⁺⁾ / methanol; tetrahydrofuran

With sodium hydroxide; N-Bromosuccinimide; diethylamino-sulfur trifluoride; oxonium; water; potassium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 125442-94-6
4-(2-Benzyloxy-4,6-dichloro-phenyl)-3,3-difluoro-butan-2-one

: 125442-85-5
7-(2-Benzyloxy-4,6-dichloro-phenyl)-6,6-difluoro-3-hydroxy-5-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / 1.) LiN(TMS)2; 2.) H₃O⁽¹⁺⁾ / tetrahydrofuran / -78 °C

2: 99 percent / 1.) NaOH, H₂O; 2.) H₃O⁽¹⁺⁾ / methanol; tetrahydrofuran

With sodium hydroxide; oxonium; water; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)88466-X