8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Base Information

• Chemical Name: 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one
• CAS No.: 118937-10-3
• Molecular Formula: C₂₇H₂₄Cl₂N₄O₃
• Molecular Weight: 523.419

Synonyms:8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

Chemical Property of 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

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Technology Process of 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

There total 2 articles about 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-benzyl-4-hydroxypiperidine-4-carbonitrile (6094-60-6) + m-chlorophenyl isocyanate (2909-38-8) → 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one (118937-10-3)

Guidance literature:

With triethylamine;

DOI:10.1021/jm00068a005

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one (118937-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium disulfide / H₂O / 1 h / 0 °C

2: 59 percent / triethylamine

With triethylamine; sodium disulfide; In water;

DOI:10.1021/jm00068a005

Reference yield: 99.0%

8-benzyl-3-(3-chlorophenyl)-4-<<(3-chlorophenyl)carbamoyl>imino>-1-oxa-3,8-diazaspiro<4.5>decan-2-one (118937-10-3) → 8-benzyl-3-(3-chlorophenyl)-1-oxa-3,8-diazaspiro<4.5>decane-2,4-dione hydrochloride

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00068a005

upstream raw materials:

1-benzyl-4-hydroxypiperidine-4-carbonitrile

m-chlorophenyl isocyanate

1-phenylmethyl-4-piperidone

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