NEUROPEPTIDE W-30 (HUMAN)

Base Information

• Chemical Name: NEUROPEPTIDE W-30 (HUMAN)
• CAS No.: 383415-80-3
• Molecular Formula: C165H249 N49 O37 S
• Molecular Weight: 3543.11
• Mol file: 383415-80-3.mol

Synonyms:16:PN: WO03057236 SEQID: 17 unclaimed protein; 17: PN: WO0198494 SEQID: 17 claimedprotein; 17: PN: WO02093161 SEQID: 17 claimed protein; 1: PN: WO2004080485SEQID: 2 claimed protein; 2: PN: WO2004041301 SEQID: 2 claimed protein; 3: PN:WO03082907 SEQID: 7 claimed protein; 476: PN: US20080312157 SEQID: 531unclaimed sequence; 47: PN: WO02092829 SEQID: 47 claimed protein; 5: PN:WO2004106382 SEQID: 5 claimed protein; 79: PN: WO0244368 SEQID: 9 claimedprotein; Neuropeptide W-30 (human); Peptide (human1-30-G-protein coupled receptor 8 ligand)

Chemical Property of NEUROPEPTIDE W-30 (HUMAN)

Chemical Property:

• Density: 1.47±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C

Purity/Quality:

99%, ^*data from raw suppliers

Neuropeptide W-30, Human ^*data from reagent suppliers

Safty Information:

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Useful:

• Biological functions: In mammals, NPW regulates many physiological processes such as food intake, energy homeostasis, obesity, neuroendocrine activity, and social behavior via its action on the CNS. In addition to the CNS, NPW and its receptors are expressed in the peripheral tissues of rodents or humans, such as the pancreas, stomach, adrenal cortex, anterior pituitary, and adipocytes. NPW may be involved in the control of adrenal corticosterone secretion, pancreatic insulin secretion, and lipolysis. Phenotype of gene-modified animals NPW knockout mice behave abnormally in response to life-threatening events (i.e., pain stimuli or a potential predator) when the environment is novel and/or distracting. NPBWR1 knockout male mice show late-onset obesity and hyperphagia, suggesting that the endogenous NPB/NPW-NPBWR1 pathway negatively regulates feeding behavior and positively regulates energy expenditure. However, these phenotypic characteristics are not observed in females.
• Description: The 23- or 30-aa neuropeptide identified as a ligand for two orphan G-protein-coupled receptors (GPR7 and GPR8), neuropeptide W (NPW) is involved in the regulation of feeding behavior and energy homeostasis via the neuronal circuits of the hypothalamus. O’Dowd et al. reported the existence of human genes encoding two structurally related orphan G protein-coupled receptors, NPBWR1 (GPR7) or NPBWR2 (GPR8).1 However, the endogenous ligand for these orphan receptors remained unknown until 2002. Shimomura et al. identified the mature peptide sequences of neuropeptide B (NPB) and neuropeptide W (NPW) from the porcine hypothalamus by reverse pharmacology.

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