2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

Base Information

Chemical Name:2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester
CAS No.:321378-00-1
Molecular Formula:C₂₆H₃₂N₂O₇
Molecular Weight:484.549
Hs Code.:

2-(4-benzyloxy-benzoylamino)-6-<i>tert</i>-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

Synonyms:2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

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Chemical Property of 2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

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Technology Process of 2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

There total 3 articles about 2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1486-50-6
4-(benzyloxy)benzoic acid chloride

: 321378-05-6
6-tert-butoxycarbonylamino-2-hydroxyimino-3-oxo-hexanoic acid methyl ester

: 321378-00-1
2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

Guidance literature:: 6-tert-butoxycarbonylamino-2-hydroxyimino-3-oxo-hexanoic acid methyl ester; With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; under 750.06 Torr;

4-(benzyloxy)benzoic acid chloride; With triethylamine; In dichloromethane;
DOI:10.1002/1099-0690(200012)2000:23<3903::AID-EJOC3903>3.0.CO;2-Q

Reference yield:

: 57294-38-9
N-(tert-butoxycarbonyl)-4-aminobutanoic acid

: 321378-00-1
2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / carbonyl diimidazole / tetrahydrofuran / 18 h / 25 °C

2.1: sodium nitrite / acetic acid; H₂O / 1 h / 0 °C

3.1: H₂; p-toluenesulfonic acid / Pd/C / methanol / 750.06 Torr

3.2: 69 percent / triethylamine / CH₂Cl₂

With hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1002/1099-0690(200012)2000:23<3903::AID-EJOC3903>3.0.CO;2-Q

Reference yield:

: 321378-03-4
6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

: 321378-00-1
2-(4-benzyloxy-benzoylamino)-6-tert-butoxycarbonylamino-3-oxo-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite / acetic acid; H₂O / 1 h / 0 °C

2.1: H₂; p-toluenesulfonic acid / Pd/C / methanol / 750.06 Torr

2.2: 69 percent / triethylamine / CH₂Cl₂

With hydrogen; toluene-4-sulfonic acid; sodium nitrite; palladium on activated charcoal; In methanol; water; acetic acid;
DOI:10.1002/1099-0690(200012)2000:23<3903::AID-EJOC3903>3.0.CO;2-Q