1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

Base Information

Chemical Name:1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid
CAS No.:1595145-14-4
Molecular Formula:C₂₆H₂₉F₃N₆O₃
Molecular Weight:530.55
Hs Code.:

Synonyms:1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

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Chemical Property of 1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

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Technology Process of 1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

There total 8 articles about 1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1595145-12-2
(R)-ethyl 1-(6-(3-((4-cyanophenylethyl)carbamoyl)piperidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidine-4-carboxylate

: 1595145-14-4
1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

Guidance literature:: (R)-ethyl 1-(6-(3-((4-cyanophenylethyl)carbamoyl)piperidin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)piperidine-4-carboxylate; With lithium hydroxide; In tetrahydrofuran; ethanol; at 25 ℃;

With hydrogenchloride; In tetrahydrofuran; ethanol; pH=3;
DOI:10.1021/jm401731q

Reference yield:

: 1595144-08-3
(R)-tert-butyl 3-((4-cyanophenylethyl)carbamoyl)piperidine-1-carboxylate

: 1595145-14-4
1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 0 °C

1.2: pH 12

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 0 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 130 °C / Sealed tube

4.1: lithium hydroxide / tetrahydrofuran; ethanol / 25 °C

4.2: pH 3

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm401731q

Reference yield:

: 1595144-10-7
C₁₅H₁₉N₃O*ClH

: 1595145-14-4
1-{6-[(3R)-3-{[2-(4-cyanophenyl)ethyl]carbamoyl}piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 0 - 25 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / 130 °C / Sealed tube

3.1: lithium hydroxide / tetrahydrofuran; ethanol / 25 °C

3.2: pH 3

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; ethanol; isopropyl alcohol;
DOI:10.1021/jm401731q