(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

Base Information

Chemical Name:(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]
CAS No.:614762-99-1
Molecular Formula:C₂₀H₂₁FN₂O₂
Molecular Weight:340.397
Hs Code.:

Synonyms:(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

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Technology Process of (4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

There total 6 articles about (4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: (7'Z,8a'S)-7'-(hydroxymethylene)-8a'-methyl-3',4',8',8a'-tetrahydro-2'H-spiro[1,3-dioxolane-2,1'-naphthalen]-6'(7'H)-one

: 614762-99-1
(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

Guidance literature:: With sodium acetate; acetic acid; In benzene; Heating;
DOI:10.1016/j.bmcl.2004.07.052

Reference yield: 41.0%

: 694526-50-6
C₁₄H₁₈O₄

: 371-14-2
4-fluorophenylhydrazine

: 614762-99-1
(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

Guidance literature:: With sodium acetate; In acetic acid; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2005.03.027

Reference yield:

: 61950-54-7
(8aS)-1,1-(1,2-ethylenedioxy)-1,2,3,4,6,7,8,8a-octahydro-8a-methyl-6-oxonaphthalene

: 614762-99-1
(4aS)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,6,7,8-hexahydrospiro[benzo[f]indazole-5,2'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaH / benzene / 3 h / 20 °C

2: 41 percent / NaOAc / acetic acid / 24 h / 20 °C

With sodium acetate; sodium hydride; In acetic acid; benzene;
DOI:10.1016/j.bmcl.2005.03.027